Referred to as squamous cell carcinoma squamous cell carcinoma, also known as epidermoid carcinoma, mainly from the squamous epithelium covering the skin. Skin and conjunctival junction of lid margin its multiple sites. Such cancer vicious extent for basal cell carcinoma. Development of faster, larger destruction. Can damage the eye tissues, invade the paranasal sinuses or intracranial, but also through the lymphatic metastasis to the preauricular or submandibular lymph nodes, and even cause systemic metastases. More common in, the elderly, men.Squamous cell carcinoma prone to transfer, and can invade the skin and mucous membranes.
Squamous cell carcinoma - Overview
Squamous cell carcinoma (squamous cell carcinoma) referred to as squamous cell carcinoma, often occur in the body of the original squamous epithelium covering the site, such as skin, mouth, lips, cervix, vagina, esophagus, larynx, Yin * stems, etc., can also be occur in other non-squamous metaplasia squamous covering parts, such as the bronchus, gall bladder, renal pelvis, etc.. The naked eye often has cauliflower-like, can also be formed necrotic ulcer-like cancer tissue at the same time to the deep invasive growth. Microscope, cancer cells were nested distribution, clear boundaries and interstitial. Well-differentiated squamous cell carcinoma nests, cells can be seen in the intercellular bridge, keratosis appear layered in the center of the cancer nests, known as keratin pearls (keratin-pearl) or cancer beads. Poorly differentiated squamous cell carcinoma of the formation of keratin pearls, and even cell bridge cell atypia and see more mitotic.
Squamous cell carcinoma
Squamous cell carcinoma related to the environment, especially the sun stimulate long-term daylight sun exposure and chronic irritation is the main incidence of latent, trauma, irradiation, tar derivatives can also induce the disease, discoid lupus erythematosus, chronic ulcers, leukoplakia, burns, bruise, and long-term healing of the flesh swelling can be induced squamous cell carcinoma.
Squamous cell carcinoma - clinical manifestations
Squamous cell cancer occurs mainly in men over the age of 50, common in the face, scalp, lower lip, the back of the hand, forearm, genitals, etc.. Especially at the junction of skin and mucous membranes more susceptible to. Since the beginning of the dark red hard wart-like nodules, the surface telangiectasia, the central horny adhesion, easy to peel, forced stripping, bleeding. Lesions gradually expanded to form a hard red patches, slightly scaly surface and a clear border infiltration to the surrounding, touch the hard, the rapid expansion of the formation of ulcers, ulcers violations of the surrounding and deep, deep muscle and bone damage to each other adhesion formation in a hard mass, difficult to move the bottom of the ulcer base, red meat, necrotic tissue, pus, odor, and easy bleeding. Ulcer edge uplift valgus, there is significant inflammation, perceived pain. Such as occurs in the skin and mucous membranes at the junction of the solid moisture and friction more bleeding, the development of faster and form a cauliflower-like, destructive, obvious pain, easy transfer of a poor prognosis.
Squamous cell carcinoma - Pathological
Epidermal hyperkeratosis, tumors of squamous cell clumps, irregular infiltration to the dermis, spinous cells were neoplastic proliferation showed cord-like or nested cell mass, angular edge of the basal cell layer, the center resistance of cancer beads, many mitotic figures in cancer cells within the Group, the surrounding lymphocytes and plasma cells.
Squamous cell carcinoma - diagnosis and differential
Clinically typical lesions and histopathology, the diagnosis is not difficult. Skin lesions, Pro-free performance, the pathological changes.
This disease should keratoacanthoma, basal cell carcinoma and other malignant skin tumors and granuloma identification. Pathological manifestations resembling grade 1-2 squamous cell carcinoma, but usually well-differentiated squamous cell, only the individual cell keratinization, nuclear proliferation and dyeing depth is slight or no, in addition to common leukocyte invasive hyperplasia of the epidermis, so that some epidermal cells collapsed, and squamous cell carcinoma does not have this phenomenon.
