Liposarcoma-About Liposarcoma:
Liposarcoma (liposarcoma) is a sarcoma. Liposarcoma is a malignant tumor originated in the primitive mesenchymal tissue, and often occurs in the thighs and the peritoneum can also be found in other parts of the soft tissue of hip popliteal fossa can occasionally rarely primary in the liver.
Liposarcoma - Overview
Liposarcoma (liposarcoma) is a sarcoma. More common in adults over the age of 40, often occurs in deep soft tissue in the thigh and retroperitoneum. Eye view of the majority of the tumors were nodular or lobulated surface layer of pseudocapsule often red and yellow, greasy feeling, and sometimes were fish-like or myxoid appearance. Microscope, the tumor cells, different size and shape of the visible star of poorly differentiated, spindle-shaped, small round or fat mother cells showed atypia and diversity, with ranging from the size of fat vacuoles in the cytoplasm, and can also be found mature fat cells. -Based differentiation and maturation of fat cells, called liposarcoma; interstitial obvious mucinous degeneration and vascular network formation, known as myxoid liposarcoma; poorly differentiated small round fat mother cells main, known as round cell liposarcoma; mainly the pleomorphic fat mother cell, known as pleomorphic liposarcoma. The latter two are highly malignant and tend to have a recurrence and metastasis.
Liposarcoma is a malignant tumor originated in the primitive mesenchymal tissue, and often occurs in the thighs and the peritoneum can also be found in other parts of the soft tissue of hip popliteal fossa can occasionally rarely primary in the liver. No characteristic clinical manifestations, liver pain, fever, appetite loss weight loss on abdominal palpable mass in the rare occurrence of jaundice and ascites.
Liposarcoma - the cause ofLiposarcoma - the cause of liposarcoma is a common malignant soft tissue tumor originated in the fat mother cell to the adipocyte differentiation of mesenchymal cells, so the performance for different degrees of abnormal fat mother cells contain lipid according to the tumor cell differentiation the extent and types can be divided into four types: differentiation of the good type myxoid, round cell and pleomorphic type tumor in the presence of multi-type cells were mixed.
Accounted for 15% of trunk subcutaneous 15% from the origin point of view, there are parts of all of the adipose tissue may occur liposarcoma limb cases accounted for 60% of peritoneal space, the original liposarcoma in the liver is extremely rare, so far reported of primary liver liposarcoma is not yet over 10 cases.
Liposarcoma - pathogenesisLiposarcoma - Primary liposarcoma of the pathogenesis of liver and other parts of the liposarcoma pathological great similarity. The tumor was ellipsoidal or irregular-shaped soft volume to often larger when the tumor section was found to grayish yellow or gray common necrotic area, necrotic area is easy to soften fragile. Around the tumor tissue pressure to form a thin layer pseudocapsule, well-differentiated liposarcoma may appear intact membrane. Microscopy liposarcoma tissue differentiation and maturation of fat cells and the differentiation of immature mesenchymal cells and shaped cytoplasmic visible lipid droplets in vacuolar nuclei were oval or round coarse deeply stained, myxoid visible cells between the rich myxoid matrix positive Alcian blue staining the surrounding liver tissue without cirrhosis.
In soft tissue sarcoma, liposarcoma is a medium degree of malignancy of the tumor 5-year survival rate of 35% to 40%, about 40% to 50% of liposarcoma of lung metastases. The main age of onset in old age. From abroad, reported four cases of liver primary liposarcoma of the two cases, two cases of middle-aged women reported two cases are adult men and women for the children of domestic cases of well-differentiated and myxoid type. No follow-up reports on the prognosis is still a lack of information.
Liposarcoma - the clinical manifestations
Liposarcoma of the liver primary liposarcoma of the early onset of obvious symptoms, with the increase of the tumor, patients with right upper quadrant dull pain, or pain are often right shoulder pain of radiation is due to tumor expansion and growth of the traction liver capsule. Is often loss of appetite, weight loss, fatigue and sometimes intractable hiccup. Liver primary liposarcoma and other malignant tumors of the liver is the patients generally jaundice performance. The number of cases have been reported in patients with tumor volume is huge, generally in a 10cm × 10cm × 10cm above the weight of several kilograms but showed no jaundice appears the Ministry of patients with right rib expansion to full physical examination, liver volume increased significantly softer texture, edge blunt thick, smooth surface, no tenderness or percussion pain, visible liver palms, spider angioma.
Complications: 1. Often appetite loss, weight loss and fatigue sometimes intractable hiccup.
(2) in patients with advanced chest and abdomen and the performance of distant metastasis and cachexia.
Liposarcoma - diagnosis
The disease difficult to diagnose before surgery, the high rate of misdiagnosis diagnosis depends on the intraoperative and postoperative pathological examination.
1 The clinical manifestations
Laboratory and other auxiliary examinations
Differential diagnosis:
This disease is extremely rare, and no specific clinical manifestations and diagnostic methods, often doctors ignore clinical, easily misdiagnosed without a history of liver cirrhosis and liver cysts liver abscess liver hemangioma, normal liver function, AFP negative, even if the huge liver mass, but no jaundice, ascites, splenomegaly and so on, helps with huge primary liver cancer differentiated liver liposarcoma is often associated with the central organization liquefaction necrosis, the formation of cysts, exactly like the liver cyst, but the patient more associated with weight loss, fever, and B super-visible capsule echo intensity ranging from wall of uneven thickness technique routinely frozen pathology, clear lesions to avoid misdiagnosis, wrong treatment.
Liposarcoma - Check
Liposarcoma - check laboratory tests: liver primary liposarcoma of the liver function damage the performance of a late enzymatic examination and AFP, CEA and other tumor markers negative, patients often found the right upper quadrant pain treatment, liver imaging check the initial diagnosis, but a definite diagnosis still need liver biopsy pathology.
Other laboratory examinations:
The imaging manifestations of this disease is quite characteristic.
1.B ultrasound visible intrahepatic huge and homogeneous echogenic area.
2.CT the performance of CT values for the sharp edges of the low-density area is small, up-90Hu intrahepatic tumor CT value of the minimum injection of contrast medium, no enhancement reaction.
3.MRI T1T2 weighted images showed high signal areas.
In imaging liver liposarcoma with hepatic lipoma is difficult to distinguish.
Liposarcoma - Treatment
Surgery is the main method for the treatment of liver liposarcoma. Well-differentiated sarcoma of the liver fat by surgical resection of primary lesions and good prognosis after the country reported one cases of patients after surgical removal volume is 20cm × 20cm × 25cm of the primary lesion, followed six months after the patients had no recurrence of the good quality of life and one patient myxoid, and 4 months in patients with relapse after surgery he died. Chemotherapy, radiotherapy and medical treatment can be used as adjunct in the comprehensive treatment program liposarcoma is less sensitive to chemotherapy, but patients with unresectable distant metastasis, the preferred chemical treatment commonly used drugs cisplatin,5-FU, N Xi Mi ammonia (DITC), doxorubicin sarcoma occurrence of bone metastases, radiotherapy is effective for pain relief measures.
Liposarcoma - Prevention
Liposarcoma is a malignant tumor originated in the primitive mesenchymal tissue, and often occurs in the thighs and the peritoneum can also be found in other parts of the soft tissue of hip popliteal fossa can occasionally rarely primary in the liver. This disease is no effective preventive measures, the main diet should be light, eat high-fat foods.
Liposarcoma - Transfer of
Histological differentiation of bad 30% to 40% of the transfer of differentiated less transfer. Can also be transferred to the liver, bone marrow, central nervous system, but for the common sites of metastases to the lung.
